1. Accelerated retinal degeneration after systemic depletion of circulating BM-derived microglia in rd7/rd7;Tg/Tg mice.
Accelerated retinal degeneration after systemic depletion of circulating BM-derived microglia in rd7/rd7;Tg/Tg mice. (A–D) The cilioretinal flatmounts and histology from rd7/rd7;Tg/Tg mice treated with vehicle at P50 (A), P60 (B) and P150 (C,D). (E–H) The cilioretinal flatmounts and histology from rd7/rd7;Tg/Tg mice treated with AP20187 at P50 (E), P60 (F) and P150 (G,H). (I) The number of rosettes in the cilioretinal flatmounts (mean ± s.d.) was determined at P50 (n=8), P60 (n=11), P80 (n=3) and P150 (n=4). (J) The number of AF spots in the cilioretinal flatmounts (mean ± s.d.) was determined at P50 (n=8), P60 (n=11), P80 (n=3) and P150 (n=4). (K) The number of nuclei in the outer nuclear layer (ONL) was significantly decreased in mice injected with AP20187 for 5 months compared with mice injected with vehicle. (L) Scheme of an eye section, showing the areas in which the ONL nuclei were counted. OD, optic disc. *P<0.05.
Nan-Kai Wang et al. Dis. Model. Mech. 2013;6:
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