1. Volume 131, Issue 6, Pages 1706-1716 (December 2006)
Dietary Factors and Biomarkers Involved in the Methylenetetrahydrofolate Reductase Genotype–Colorectal Adenoma Pathway 
María Elena Martínez, Patricia Thompson, Elizabeth T. Jacobs, Edward Giovannucci, Ruiyun Jiang, Walt Klimecki, David S. Alberts 
Gastroenterology 
Volume 131, Issue 6, Pages (December 2006)
DOI: /j.gastro
Copyright © 2006 AGA Institute Terms and Conditions

2. Figure 1
Proposed pathway for the effect of MTHFR genotypes on risk of colorectal adenoma. Polymorphisms in the MTHFR gene result in high homocysteine concentrations. If homocysteine is not removed, SAH accumulation will occur, resulting in a higher SAH:SAM ratio; higher concentrations of these 2 products can lead to DNA hypomethylation. This pathway is especially important in the presence of low folate status.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2006 AGA Institute Terms and Conditions