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M Sawano, T Mato, H Tsutsumi  British Journal of Anaesthesia 

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Presentation on theme: "M Sawano, T Mato, H Tsutsumi  British Journal of Anaesthesia "— Presentation transcript:

1 Bedside red cell volumetry by low-dose carboxyhaemoglobin dilution using expiratory gas analysis 
M Sawano, T Mato, H Tsutsumi  British Journal of Anaesthesia  Volume 96, Issue 2, Pages (February 2006) DOI: /bja/aei302 Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

2 Fig 1 Differences between inspiratory and expiratory gas CO concentration (exCO–inCO) were plotted against differences between inspiratory and expiratory gas carbon dioxide concentration (exCO2–inCO2), at a random respiratory phase. COHb% was fixed for each subject. Solid lines and equation (y=Ax+B) represent linear regression equation. R2 represent correlation coefficients. British Journal of Anaesthesia  , DOI: ( /bja/aei302) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

3 Fig 2 Time series data of COHb% continuously measured by EGA. Arrow indicates time at which infusion of 50 ml of carbon-monoxide-saturated blood was completed (Tinf). The two lower graphs show magnification of the early phases in semi-logarithmic scale (subjects 1 and 6). Solid line represents COHb% diminution curve used to calculate COHb% increment. British Journal of Anaesthesia  , DOI: ( /bja/aei302) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

4 Fig 3 One-minute averages of COHb% measured by EGA and simultaneous measurement by CO-haemoximetry, for healthy subjects. Differences between these measurements were plotted against the means. Solid line represents mean of differences (bias), and dotted lines represent mean (2 sd) (‘limits of agreement’). British Journal of Anaesthesia  , DOI: ( /bja/aei302) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

5 Fig 4 One-minute averages of COHb% measured by EGA and simultaneous measurement by CO-haemoximetry, for patients with artificially controlled ventilation. Differences between these measurements were plotted against the means. Solid line represents mean of differences (bias), and dotted lines represent mean (2 sd) (‘limits of agreement’). British Journal of Anaesthesia  , DOI: ( /bja/aei302) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

6 Fig 5 RCV was measured using EGA with infusion of 20 ml of CO-saturated blood (RCVEGA), and was also measured using CO-haemoximetry with 100 ml infusion (RCVHEM), Differences between these measurements were plotted against the means. Solid line represents mean of differences (bias), and dotted lines represent mean (2 sd) (‘limits of agreement’). British Journal of Anaesthesia  , DOI: ( /bja/aei302) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

7 Fig 6 (a) The two-alveoli model. Equations on both sides represent equivalence of CO and carbon dioxide (CO2) tensions between alveoli and capillaries. The equations at the bottom represent calculations of end tidal and arterial CO–CO2 tension ratios (Pe′CO/Pe′CO2, PaCO/PaCO2) from ventilation (VX,VY), perfusion (QX,QY), CO and CO2 tensions in alveoli (PaxCO, PaxCO2, PayCO, PayCO2) and capillaries (PcxCO, PcxCO2, PcyCO, PcyCO2). (b,c) Two patterns of VQ mismatch. In the ‘dead space’ pattern (b), alveolus X is ventilated but not perfused (QX=0). CO and CO2 tension in alveoli with no perfusion are assumed to be zero (PaxCO=PaxCO2=0). In the ‘shunt’ pattern (c), alveolus X is perfused but not ventilated (VX=0). British Journal of Anaesthesia  , DOI: ( /bja/aei302) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

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