1. GLP-1 and gastrin combination therapy restores normoglycemia in NOD mice.
GLP-1 and gastrin combination therapy restores normoglycemia in NOD mice. Beginning 3–6 days after diabetes onset (0 weeks) and for the next 3 weeks, NOD mice were treated with twice-daily intraperitoneal injections of vehicle (n = 6), 10 μg/kg GLP-1 (n = 7), 100 μg/kg GLP-1 (n = 7), 1.5 μg/kg gastrin (n = 4), 10 μg/kg GLP-1 plus 1.5 μg/kg gastrin (n = 6), and 100 μg/kg GLP-1 plus 1.5 μg/kg gastrin (n = 7). Blood glucose concentrations in individual mice are shown during the 3 weeks of treatments and for the additional 5 weeks after treatments were stopped. †Mice with blood glucose levels ≥27.5 mmol/l and losing weight were killed. Shaded bars show the normal range for blood glucose (3.5–6.5 mmol/l).
Wilma L. Suarez-Pinzon et al. Diabetes 2008;57:
©2008 by American Diabetes Association