1. Perfusion CT to Assess Response to Neoadjuvant Chemotherapy and Radiation Therapy in Pancreatic Ductal Adenocarcinoma: Initial
Experience
After neoadjuvant chemotherapy and radiation therapy (CRT) for pancreatic adenocarcinoma, pretreatment blood flow at perfusion CT was higher in responders than in nonresponders (44 vs 28 mL/100 g/min, respectively; P = .04).
For patients who responded to neoadjuvant CRT, blood flow increased after CRT (54 vs 43 mL/100 g/min, respectively; P = .04).
Images in 70-year-old man with borderline resectable pancreatic-head adenocarcinoma (arrow). Perfusion and conventional contrast-enhanced CT images after (bottom row) neoadjuvant chemoradiation therapy. Pre-CRT blood flow was 14 mL/100 g/min and increased mildly after CRT to 18 mL/100 g. Histopathologic evaluation of response revealed poor response to therapy.
Hamdy A et al. Perfusion CT to Assess Response to Neoadjuvant Chemotherapy and Radiation Therapy in Pancreatic Ductal Adenocarcinoma: Initial Experience.
Published Online: July 9,