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Identifying TRK Fusions in Head and Neck Cancer

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Presentation on theme: "Identifying TRK Fusions in Head and Neck Cancer"— Presentation transcript:

1 Identifying TRK Fusions in Head and Neck Cancer

2

3 Introduction

4 Overview of NTRK

5 NTRK Fusions

6 Frequency of NTRK Fusions

7 NTRK Fusions in Salivary Gland and Thyroid Cancers

8 Identifying Appropriate Patients for NTRK Testing

9 Identifying Appropriate Patients for NTRK Testing, cont

10 Challenges in Identifying Secretory Histology in Salivary Gland Cancer

11 Optimal Timing for NTRK Testing

12 NTRK Fusions vs Point Mutations

13 Testing for TRK Fusions

14 NTRK Inhibitors

15 Overview of Larotrectinib Clinical Trials

16 Larotrectinib in Subset of Patients With Salivary Gland and Thyroid Cancers

17 Larotrectinib in Subset of Patients With Salivary Gland and Thyroid Cancers (cont)

18 Larotrectinib Clinical Trials: 2019 Update

19 Select Larotrectinib TRAEs in Clinical Trials

20 Overview of Entrectinib Clinical Trials

21 Resistance to TRK Inhibitors

22 LOXO-195 in Larotrectinib-Resistant Patients

23 Repotrectinib in Larotrectinib-Resistant Patients

24 Unanswered Questions

25 Summary and Conclusions

26 Abbreviations

27 Abbreviations (cont)


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