1. ATL-801 treatment increases insulin sensitivity in KKAY mice.
ATL-801 treatment increases insulin sensitivity in KKAY mice. ATL-801 was administered by oral gavage 4 times at 12-h internals with the last dose given 4 h before clamp. A: Body weight change during ATL-801 administration. B: Basal plasma glucose levels. C: Plasma glucose levels during clamps. D: Steady-state glucose infusion rates during clamps. E: Insulin-stimulated skeletal muscle glucose uptake. F: Insulin-stimulated glucose uptake in brown adipose tissue. G: Basal HGP. H: HGP during clamps (insulin-stimulated state). I: Hepatic insulin action reflected as insulin-mediated percent suppression of basal HGP. *P < 0.05 by two-tailed Student t test; N = 7.
Robert A. Figler et al. Diabetes 2011;60:
©2011 by American Diabetes Association