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Effects of obesity and bariatric surgery on airway hyperresponsiveness, asthma control, and inflammation Anne E. Dixon, MA, BM BCh, Richard E. Pratley, MD, Patrick M. Forgione, MD, David A. Kaminsky, MD, Laurie A. Whittaker-Leclair, MD, Laurianne A. Griffes, BA, Jayanthi Garudathri, MS, Danielle Raymond, BS, Mathew E. Poynter, PhD, Janice Y. Bunn, PhD, Charles G. Irvin, PhD Journal of Allergy and Clinical Immunology Volume 128, Issue 3, Pages e2 (September 2011) DOI: /j.jaci Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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Fig 1 Enrollment and follow-up of study participants. Participants were initially enrolled before bariatric surgery, although only participants who actually went through bariatric surgery were included in the analysis. There were 6 asthmatic and no control participants who did not have bariatric surgery. This was related to the fact that asthmatic patients were enrolled at presentation to the bariatric clinic, whereas control participants were only enrolled once their surgery had been scheduled. Journal of Allergy and Clinical Immunology , e2DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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Fig 2 Change in AHR in patients with normal IgE (A) (P = .001), n = 11 and elevated IgE (B) (P = .89). Squares represent median values. A significant interaction term exists between IgE status and change in AHR (P = .01 for interaction term). Journal of Allergy and Clinical Immunology , e2DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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Fig 3 Cytokine production from CD3-CD28–stimulated CD4+ T lymphocytes before and 12 months after bariatric surgery in control subjects (n = 15) and asthmatic patients (n = 10). P values were shown for comparison of asthmatic patients at 0 and 12 months, and there were no significant differences between asthmatic patients and control subjects at visit 0. Journal of Allergy and Clinical Immunology , e2DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions
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