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PLI and PLIII are activating ligands for MR1Ts.

Published byVera Chandra Modified over 5 years ago

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Presentation on theme: "PLI and PLIII are activating ligands for MR1Ts."— Presentation transcript:

1 PLI and PLIII are activating ligands for MR1Ts.
PLI and PLIII are activating ligands for MR1Ts. (A) MS2 fragment spectra of precursor ion in the indicated sample, indicating that synthetic PLI matches the eluted ion in hpMR1+MS. (B) MS2 fragment spectra of precursor ion in the indicated sample, indicating that synthetic PLIII matches the eluted ion in hpMR1+EC and hpMR1+MS. (C) MR1T clone responses to DC pulsed with PLI or PLIII at the indicated concentration. (D) MR1 cell clone D481C7 or D426G11 responses to DC incubated with synthetic PLI, PLIII, RL-6,7-diMe (DMRL), or RL-6-Me-7-OH (HMRL), at 1.56 to 200 μM, or M. smegmatis (Msm), Msm-sup, or PHA. (E) Left: The D481C7 MR1T clone response to DC pulsed with PLI or PLIII was blocked with the anti-MR1 blocking antibody. Right: 6-FP was added at increasing concentrations to DC before pulsing with PLI or PLIII. Results in (C) and (D) are representative of three independent experiments. Error bars represent means and SD from technical replicates. Melanie J. Harriff et al. Sci. Immunol. 2018;3:eaao2556 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

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