1. Reduced OXPHOS expression and increased UCP expression.
Reduced OXPHOS expression and increased UCP expression. A: Myocardial gene expression in 24-week-old wild-type (WT) and Akita mice normalized to 16S RNA transcript levels (n = 8). Values represent fold change in mRNA transcript levels relative to wild type, which was assigned as one (dashed line). B: Representative Western blot images and densitometric quantification of UCP3 protein levels in isolated mitochondria from 24-week-old wild-type and Akita mice (n = 4). Coomassie blue staining was used as a loading control. *P < 0.05 vs. wild type.
Heiko Bugger et al. Diabetes 2008;57:
©2008 by American Diabetes Association