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Tariq A. Mukhtar, Kalinka P. Koteva, Gerard D. Wright 

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Presentation on theme: "Tariq A. Mukhtar, Kalinka P. Koteva, Gerard D. Wright "— Presentation transcript:

1 Chimeric Streptogramin-Tyrocidine Antibiotics that Overcome Streptogramin Resistance 
Tariq A. Mukhtar, Kalinka P. Koteva, Gerard D. Wright  Chemistry & Biology  Volume 12, Issue 2, Pages (February 2005) DOI: /j.chembiol Copyright © 2005 Elsevier Ltd Terms and Conditions

2 Figure 1 Solid-Phase Chemoenzymatic and Chemical Strategies Employed in Chimeric Peptide Synthesis Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2005 Elsevier Ltd Terms and Conditions

3 Figure 2 Dissection of Streptogramin-Tyrocidine Chimeric Antimicrobial Peptides Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2005 Elsevier Ltd Terms and Conditions

4 Figure 3 Structures of Antimicrobial Peptides Synthesized and Assayed in This Work Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2005 Elsevier Ltd Terms and Conditions

5 Figure 4 Impact of Antibiotics on In Vitro Translation
Antibiotics were added to a final concentration of 0.1 mg/ml and the amount of [35S]-Met incorporated into in vitro translated chloramphenicol acetyltransferase quantified and normalized to the DMSO carrier control. The average of two experiments is presented. Duplicate values were within 6% of each other. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2005 Elsevier Ltd Terms and Conditions


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