1. Adoptive transfer of purified activated G9Cα−/−
Adoptive transfer of purified activated G9Cα−/−.NOD CD8 T-cells into NOD.scid mice.
Adoptive transfer of purified activated G9Cα−/−.NOD CD8 T-cells into NOD.scid mice. G9Cα−/−.NOD CD8 T-cells were purified and cultured with matured bone marrow–derived dendritic cells together with 0.5 μg/ml insulin B15-23 peptide for 3 days. After washing, the cells were intravenously injected into 6-week-old NOD.scid mice (n = 8). Mice were tested daily for glycosuria and diabetes confirmed by blood glucose >13.9mmol/l.
F. Susan Wong et al. Diabetes 2009;58:
©2009 by American Diabetes Association