1. Innate immune and fibrinolytic systems cooperate also during bacterial infections.
Innate immune and fibrinolytic systems cooperate also during bacterial infections. (A) Kaplan-Meier curve showing the percentage of WT (n = 6) and IFN-γ–deficient mice (n = 10) undergoing ulceration after S. aureus administration at the indicated time points; log-rank test. Representative data of two independent experiments. (B) Hematoxylin and eosin staining of WT and IFN-γ–deficient mice skin lesions 48 hours after S. aureus infection. PicroSirius Red staining is also shown to evidence collagen depositions. (C) Western blot analysis of SMAD2/3 phosphorylation at the indicated time points after S. aureus infection of WT and IFN-γ–deficient mice. Data were quantified and normalized on β-actin. Data are representative of three independent experiments. (D) Western blot analysis of tPA and PAI-1 levels measured in WT and IFN-γ–deficient animals at the indicated hours after S. aureus infection.
William Santus et al. Sci. Immunol. 2017;2:eaan2725
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