1. Anemia Explored

3. ESA Resistance or Hyporesponsiveness

4. Evolution of Managing Anemia in CKD

5. ESA Use in CKD and CV Outcomes Trials

6. Evolution of Treatment Strategies for Anemia

7. HIF-PH Inhibitors Under Development*

8. Erythropoietic Response via HIF

9. HIF-PHI Mechanism of Action

10. FDA Boxed Warning on Use of ESAs

11. Next Big Question Is….

12. Hypothetical Mechanisms of EPO-Induced Hypertension

13. How Will HIF-PHIs Impact Patient Reported Outcomes?

14. Meta-Analysis of HIF-PHI Studies

15. Potential Clinical Impact of HIF-PHIS

16. Safety of HIF-PHIs

17. Role of Iron in Treating Anemia

18. Clinical Impact of HIF-PHIs on Iron Use

19. Abbreviations

20. Abbreviations (cont)