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Published byTeguh Indra Kusumo Modified over 5 years ago
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Human Herpes Virus 6 Plasma DNA Positivity after Hematopoietic Stem Cell Transplantation in Children: an Important Risk Factor for Clinical Outcome P.J. Anne de Pagter, Rob Schuurman, Henk Visscher, Machiel de Vos, Marc Bierings, Anton M. van Loon, Cuno S.P.M. Uiterwaal, Debbie van Baarle, Elisabeth A.M. Sanders, JaapJan Boelens Biology of Blood and Marrow Transplantation Volume 14, Issue 7, Pages (July 2008) DOI: /j.bbmt Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions
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Figure 1 DNA loads of viral reactivations after HSCT. #Fifteen of 58 patients were CMV seropositive and had a CMV-seropositive donor (D+R+), 14 of 58 were CMV seropositive but had a CMV seronegative donor (D−R+), 8 of 58 patients were CMV seronegative but had CMV a seropositive donor (D+R−), and 21/58 patients were CMV seronegative with a seronegative donor (D−R−). ∗Twenty-eight of 58 patients were EBV D+R+, 11 of 58 patients were D−R+, 8 of 58 patients were D+R−, and 11 of 58 patients were D−R−. ¥ Based on the literature, we suspect all patients to be Adenovirus seropositive. Gender, indication, donor type, cell source, conditioning regimen, and HLA-matching did not significantly differ between patients at risk or not at risk for viral reactivation after HSCT. Additionally, 18 of 58 patients were at risk for HSV reactivation and 36 of 58 recipients were at risk for VZV reactivation. Biology of Blood and Marrow Transplantation , DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions
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Figure 2 Kaplan-Meier survival curve after HSCT.
Biology of Blood and Marrow Transplantation , DOI: ( /j.bbmt ) Copyright © 2008 American Society for Blood and Marrow Transplantation Terms and Conditions
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