Presentation is loading. Please wait.

Presentation is loading. Please wait.

Pediatric experience with mipomersen as adjunctive therapy for homozygous familial hypercholesterolemia  Frederick J. Raal, PhD, Marjet J. Braamskamp,

PublishAron Mills Modified over 5 years ago

Similar presentations

Presentation on theme: "Pediatric experience with mipomersen as adjunctive therapy for homozygous familial hypercholesterolemia  Frederick J. Raal, PhD, Marjet J. Braamskamp,"— Presentation transcript:

1 Pediatric experience with mipomersen as adjunctive therapy for homozygous familial hypercholesterolemia  Frederick J. Raal, PhD, Marjet J. Braamskamp, MD, PhD, Sheryl L. Selvey, PharmD, Charlotte H. Sensinger, MA, John J. Kastelein, MD, PhD  Journal of Clinical Lipidology  Volume 10, Issue 4, Pages (July 2016) DOI: /j.jacl Copyright © 2016 Sanofi-Genzyme Terms and Conditions

2 Figure 1 Mipomersen mechanism of action. apo B–100, apolipoprotein B–100; LDL-C, low-density lipoprotein cholesterol; mRNA, messenger ribonucleic acid; RNase H, ribonuclease H; VLDL, very low density lipoprotein. Reprinted from the Journal of the American College of Cardiology, Vol. 62/No.23, Thomas GS, Cromwell WC, Ali S, Chin W, Flaim JD, Davidson M, Mipomersen, an apolipoprotein B synthesis inhibitor, reduces atherogenic lipoproteins in patients with severe hypercholesterolemia at high cardiovascular risk: A Randomized, Double-Blind, Placebo-Controlled Trial, pp 2178–2184, Copyright 2013, with permission from the American College of Cardiology Foundation. Journal of Clinical Lipidology  , DOI: ( /j.jacl ) Copyright © 2016 Sanofi-Genzyme Terms and Conditions

3 Figure 2 Pediatric patient flow in randomized controlled trial and open-label extension. ALT, alanine aminotransferase; AST, aspartate aminotransferase; OLE, open-label extension study; RCT, randomized controlled trial. Journal of Clinical Lipidology  , DOI: ( /j.jacl ) Copyright © 2016 Sanofi-Genzyme Terms and Conditions

4 Figure 3 Low-density lipoprotein cholesterol concentration at measured time points in the randomized controlled trial and the open-label extension study. LDL-C, low-density lipoprotein cholesterol; OLE, open-label extension study; RCT, randomized controlled trial. Journal of Clinical Lipidology  , DOI: ( /j.jacl ) Copyright © 2016 Sanofi-Genzyme Terms and Conditions

5 Figure 4 Apo B concentration at measured time points in the randomized controlled trial and the open-label extension study. apo B, apolipoprotein B; OLE, open-label extension study; RCT, randomized controlled trial. Journal of Clinical Lipidology  , DOI: ( /j.jacl ) Copyright © 2016 Sanofi-Genzyme Terms and Conditions

6 Figure 5 Lipoprotein(a) concentration at measured time points in the randomized controlled trial and the open-label extension study. Lp(a), lipoprotein(a); OLE, open-label extension study; RCT, randomized controlled trial. Journal of Clinical Lipidology  , DOI: ( /j.jacl ) Copyright © 2016 Sanofi-Genzyme Terms and Conditions

Download ppt "Pediatric experience with mipomersen as adjunctive therapy for homozygous familial hypercholesterolemia  Frederick J. Raal, PhD, Marjet J. Braamskamp,"

Similar presentations

Corn oil improves the plasma lipoprotein lipid profile compared with extra-virgin olive oil consumption in men and women with elevated cholesterol: Results.

Corn oil improves the plasma lipoprotein lipid profile compared with extra-virgin olive oil consumption in men and women with elevated cholesterol: Results.
Interrupting bile-acid handling and lipid and glucose control: Effects of colesevelam on glucose levels  Michael H. Davidson, MD  Journal of Clinical.

Interrupting bile-acid handling and lipid and glucose control: Effects of colesevelam on glucose levels  Michael H. Davidson, MD  Journal of Clinical.
Lipid abnormalities in foreign-born and US-born patients in a medical group  Jawali Jaranilla, MD, MPH, Terese DeFor, MS, Gabriela Vazquez Benitez, PhD,

Lipid abnormalities in foreign-born and US-born patients in a medical group  Jawali Jaranilla, MD, MPH, Terese DeFor, MS, Gabriela Vazquez Benitez, PhD,
Lipoprotein(a), Cardiovascular Disease, and Contemporary Management

Lipoprotein(a), Cardiovascular Disease, and Contemporary Management
Patient and Physician Perspectives on Administration of the PCSK9 Monoclonal Antibody Alirocumab, an Injectable Medication to Lower LDL-C Levels†  Eli.

Patient and Physician Perspectives on Administration of the PCSK9 Monoclonal Antibody Alirocumab, an Injectable Medication to Lower LDL-C Levels†  Eli.
Charles R. Harper, MD, Terry A. Jacobson, MD  Mayo Clinic Proceedings 

Charles R. Harper, MD, Terry A. Jacobson, MD  Mayo Clinic Proceedings 
2013 Cholesterol Guidelines Revisited: Percent LDL Cholesterol Reduction or Attained LDL Cholesterol Level or Both for Prognosis?  Sripal Bangalore, MD,

2013 Cholesterol Guidelines Revisited: Percent LDL Cholesterol Reduction or Attained LDL Cholesterol Level or Both for Prognosis?  Sripal Bangalore, MD,
Corn oil improves the plasma lipoprotein lipid profile compared with extra-virgin olive oil consumption in men and women with elevated cholesterol: Results.

Corn oil improves the plasma lipoprotein lipid profile compared with extra-virgin olive oil consumption in men and women with elevated cholesterol: Results.
Efficacy and safety of the proprotein convertase subtilisin/kexin type 9 monoclonal antibody alirocumab vs placebo in patients with heterozygous familial.

Efficacy and safety of the proprotein convertase subtilisin/kexin type 9 monoclonal antibody alirocumab vs placebo in patients with heterozygous familial.
Efficacy of alirocumab in high cardiovascular risk populations with or without heterozygous familial hypercholesterolemia: Pooled analysis of eight ODYSSEY.

Efficacy of alirocumab in high cardiovascular risk populations with or without heterozygous familial hypercholesterolemia: Pooled analysis of eight ODYSSEY.
2016 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult  Todd J.

2016 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult  Todd J.
Purified palmitoleic acid for the reduction of high-sensitivity C-reactive protein and serum lipids: A double-blinded, randomized, placebo controlled.

Purified palmitoleic acid for the reduction of high-sensitivity C-reactive protein and serum lipids: A double-blinded, randomized, placebo controlled.
Charles R. Harper, MD, Terry A. Jacobson, MD  Mayo Clinic Proceedings 

Charles R. Harper, MD, Terry A. Jacobson, MD  Mayo Clinic Proceedings 
Rounding numbers The Journal of Thoracic and Cardiovascular Surgery

Rounding numbers The Journal of Thoracic and Cardiovascular Surgery
Efficacy and safety of gemcabene as add-on to stable statin therapy in hypercholesterolemic patients  Evan Stein, MD, Harold Bays, MD, Michael Koren,

Efficacy and safety of gemcabene as add-on to stable statin therapy in hypercholesterolemic patients  Evan Stein, MD, Harold Bays, MD, Michael Koren,
KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 Update

KDOQI Clinical Practice Guideline for Diabetes and CKD: 2012 Update
Emerging LDL therapies: Mipomersen—antisense oligonucleotide therapy in the management of hypercholesterolemia  Peter P. Toth, MD, PhD, FAAFP, FICA, FNLA,

Emerging LDL therapies: Mipomersen—antisense oligonucleotide therapy in the management of hypercholesterolemia  Peter P. Toth, MD, PhD, FAAFP, FICA, FNLA,
Omega-3 carboxylic acids in patients with severe hypertriglyceridemia: EVOLVE II, a randomized, placebo-controlled trial  Erik S.G. Stroes, MD, PhD, Andrey.

Omega-3 carboxylic acids in patients with severe hypertriglyceridemia: EVOLVE II, a randomized, placebo-controlled trial  Erik S.G. Stroes, MD, PhD, Andrey.
Glucagon-like peptide-1 receptor agonists reduced the low-density lipoprotein cholesterol in Japanese patients with type 2 diabetes mellitus treated with.

Glucagon-like peptide-1 receptor agonists reduced the low-density lipoprotein cholesterol in Japanese patients with type 2 diabetes mellitus treated with.
Efficacy and safety of pemafibrate (K-877), a selective peroxisome proliferator-activated receptor α modulator, in patients with dyslipidemia: Results.

Efficacy and safety of pemafibrate (K-877), a selective peroxisome proliferator-activated receptor α modulator, in patients with dyslipidemia: Results.

Similar presentations

Ads by Google