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Published byJukka-Pekka Mattila Modified over 5 years ago
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Balancing the Risks and Benefits of Multidrug Regimens in the Clinical Management of Nontuberculous Mycobacterial Lung Disease
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Program Overview
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NTM Lung Disease Introduction
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Radiographic Manifestations
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Predisposing Factors
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Managing NTM Lung Disease Can Be Challenging
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Determining Who To Treat
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Guideline-Based Recommendations for Treating NTM Lung Disease
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Standard Treatment for MAC, Macrolide-Susceptible Disease
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Standard Treatment for MAC, Macrolide-Susceptible Disease (cont)
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When Is Treatment NOT Indicated?
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Treatment-Related AEs Standard Care
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Monitoring Response
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Unresolved Questions
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Unresolved Questions (cont)
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Unresolved Questions (cont)
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Benefits of Inhaled Therapies
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ALIS Overview
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Phase 2 Trial ALIS
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Treatment-Related AEs ALIS vs Placebo
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Findings ALIS Phase 2 Trial
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Phase 3 Trial CONVERT
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Findings CONVERT Trial
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Treatment-Related AEs CONVERT Trial
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Who Best Benefits From ALIS?
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Bedaquiline Overview
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Case Series Bedaquiline
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Treatment-Related AEs Bedaquiline
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Oxazolidinones Tedizolid, Linezolid Overview
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Clofazimine Overview
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Treatment-Related AEs Clofazimine
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Nitric Oxide Overview
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Concluding Remarks
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Abbreviations
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