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Peanut oral immunotherapy decreases IgE to Ara h 2 and Ara h 6 but does not enhance sensitization to cross-reactive allergens  Riikka Uotila, MD, Anna.

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Presentation on theme: "Peanut oral immunotherapy decreases IgE to Ara h 2 and Ara h 6 but does not enhance sensitization to cross-reactive allergens  Riikka Uotila, MD, Anna."— Presentation transcript:

1 Peanut oral immunotherapy decreases IgE to Ara h 2 and Ara h 6 but does not enhance sensitization to cross-reactive allergens  Riikka Uotila, MD, Anna Kaarina Kukkonen, MD, PhD, Dario Greco, PhD, Anna Susanna Pelkonen, MD, PhD, Mika Juhani Mäkelä, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 139, Issue 4, Pages e6 (April 2017) DOI: /j.jaci Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Serum peanut allergen-specific IgE measured with ISAC microarray before and after peanut OIT build-up phase. *Omitted from microarray data analysis. Only allergens with ≥50% + 1 patients sensitized (≥0.3 ISU-E) in ≥1of 4 groups (OIT pre, OIT post, avoidance pre, avoidance post) are included in order to ensure the representativeness of the given allergen. See the Methods in this article's Online Repository (available at Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 IgG4-IgE ratios to peanut allergens and whole peanut extract measured with ImmunoCAP before and after peanut OIT build-up phase. Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E1 Sensitization prevalences (%) to individual allergens in protein families cross-reactive to peanut. Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E2 Changes in the levels of specific IgG4 to Ara h 2, Ara h 6, and whole peanut extract measured with ImmunoCAP in (A) OIT group and (B) avoidance group before and after peanut OIT build-up phase. Journal of Allergy and Clinical Immunology  , e6DOI: ( /j.jaci ) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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