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Fig. 4. Deletion of Baf60c in myocardium results in dilated chambers and impaired cardiac function. Deletion of Baf60c in myocardium results in dilated.

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Presentation on theme: "Fig. 4. Deletion of Baf60c in myocardium results in dilated chambers and impaired cardiac function. Deletion of Baf60c in myocardium results in dilated."— Presentation transcript:

1 Fig. 4. Deletion of Baf60c in myocardium results in dilated chambers and impaired cardiac function.
Deletion of Baf60c in myocardium results in dilated chambers and impaired cardiac function. (A) Baf60cfl/−;Myh6::Cre mice all die before 4 months of age. Fraction of remaining mice of each genotype is graphed. Initial number was 129 (37 flox/+, 36 flox/+;Cre, 26 flox/-, 30 flox/-;Cre). (B) Baf60cfl/−;Myh6::Cre mice have enlarged hearts and dilated chambers, as shown with whole-mount (top panel) and four-chamber view sections (middle panel). Left panel: P10. Right panel: 8-week hearts. Masson trichrome staining detects fibrosis in ventricle myocardium (bottom panels, arrowheads). (C) Baf60cMyh6KO myocardium have high levels of apoptosis. Green, TUNEL; blue, DAPI. (D) Representative electrocardiogram of adult WT and Baf60cfl/−;Myh6::Cre mice. Xin Sun et al. Biology Open 2018;7:bio029512 © Published by The Company of Biologists Ltd

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