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Segmentation Genes Enter an Excited State

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1 Segmentation Genes Enter an Excited State
Akihiro Isomura, Hiroshi Kori, Ryoichiro Kageyama  Developmental Cell  Volume 43, Issue 2, Pages (October 2017) DOI: /j.devcel Copyright © 2017 Elsevier Inc. Terms and Conditions

2 Figure 1 LuVeLu Oscillations under the Control of Yap and Notch Signaling (A) A negative-feedback genetic oscillator system. This system displays responses with graded amplitudes but a constant frequency. (B) An excitable system. Stimulation over a threshold elicits responses with a constant amplitude but graded frequencies. (C–H) LuVeLu expression (green lines) and Yap signaling activity. (C) Dissociated cells on fibronectin. (D) Re-aggregated cells on fibronectin. (E) Re-aggregated cells on fibronectin with the Notch inhibitor DAPT. (F) Dissociated cells on fibronectin with the Notch ligand Dll1. (G) Dissociated cells on BSA. (H) Dissociated cells on fibronectin with the actin polymerization inhibitor latrunculin A (LatA), which represses Yap signaling. Developmental Cell  , DOI: ( /j.devcel ) Copyright © 2017 Elsevier Inc. Terms and Conditions

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