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Optimized ventricular restraint therapy: Adjustable restraint is superior to standard restraint in an ovine model of ischemic cardiomyopathy  Lawrence.

Published byAlexandra Daniela Bednářová Modified over 5 years ago

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Presentation on theme: "Optimized ventricular restraint therapy: Adjustable restraint is superior to standard restraint in an ovine model of ischemic cardiomyopathy  Lawrence."— Presentation transcript:

1 Optimized ventricular restraint therapy: Adjustable restraint is superior to standard restraint in an ovine model of ischemic cardiomyopathy  Lawrence S. Lee, MD, Ravi K. Ghanta, MD, Suyog A. Mokashi, MD, Otavio Coelho-Filho, MD, Raymond Y. Kwong, MD, Michael Kwon, MD, Jian Guan, MS, Ronglih Liao, PhD, Frederick Y. Chen, MD, PhD  The Journal of Thoracic and Cardiovascular Surgery  Volume 145, Issue 3, Pages (March 2013) DOI: /j.jtcvs Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 Representative cardiac magnetic resonance imaging short-axis section (delayed enhancement series) of heart failure ovine subject. Infarcted area is white and identified by upper arrow. The adjustable and measurable ventricular restraint (AMVR) device is identified by lower arrows and the fluid within the device can be clearly seen as black. The AMVR device surrounds the entire heart but is only partially seen here owing to the cut of this particular image. LV, Left ventricle. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 Mean change in left ventricular end-diastolic volume (LV EDV) after restraint device implantation for the low and high restraint groups. *P < .05 for change in LV EDV from time zero (start of restraint therapy). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 Rate of reverse remodeling (change in left ventricular end-diastolic volume [LV EDV] per week) for the low and high restraint groups in part I. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

5 Figure 4 Mean change in left ventricular end-diastolic volume (LV EDV) (A) and left ventricular ejection fraction (LV EF) (B) after restraint device implantation for the adjustable and standard restraint groups in part II. *P < .05 for change in LV EDV from time zero (start of restraint therapy). The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

6 Figure 5 Plasma brain natriuretic peptide (BNP) levels in the adjustable and standard restraint groups. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

7 Figure 6 Myocardial matrix metalloproteinase-2 (MMP-2) levels in the normal, border, and infarct zones for the adjustable, standard, and control groups. MMP-2 levels are highest in the infarct zone for all subjects. MMP-2 levels are significantly higher in the control group than either restraint treatment group. IR, Infrared. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2013 The American Association for Thoracic Surgery Terms and Conditions

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