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Decreased KATP activity for SUR1 (ABCC8) channels harboring R1420H or R1420C mutations. Decreased KATP activity for SUR1 (ABCC8) channels harboring R1420H.

Published byJudit Molnárné Modified over 5 years ago

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Presentation on theme: "Decreased KATP activity for SUR1 (ABCC8) channels harboring R1420H or R1420C mutations. Decreased KATP activity for SUR1 (ABCC8) channels harboring R1420H."— Presentation transcript:

1 Decreased KATP activity for SUR1 (ABCC8) channels harboring R1420H or R1420C mutations.
Decreased KATP activity for SUR1 (ABCC8) channels harboring R1420H or R1420C mutations. Relative 86Rb+ efflux is shown as a function of time under basal conditions, in the presence of metabolic inhibition (MI), in the presence of KATP channel opener diazoxide, and for both control cells expressing green fluorescent protein and cells expressing R1420R, R1420H, or R1420C channels. Data are shown as mean ± SEM from four independent transfections. *P < 0.05, **P < 0.01 vs. R1420R for each case. Leslie J. Baier et al. Diabetes 2015;64: ©2015 by American Diabetes Association

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