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Subepithelial collagen deposition, profibrogenic cytokine gene expression, and changes after prolonged fluticasone propionate treatment in adult eosinophilic.

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Presentation on theme: "Subepithelial collagen deposition, profibrogenic cytokine gene expression, and changes after prolonged fluticasone propionate treatment in adult eosinophilic."— Presentation transcript:

1 Subepithelial collagen deposition, profibrogenic cytokine gene expression, and changes after prolonged fluticasone propionate treatment in adult eosinophilic esophagitis: A prospective study  Alfredo J. Lucendo, MD, PhD, FEBG, Ángel Arias, BSc, Livia C. De Rezende, MD, PhD, Jose Luis Yagüe-Compadre, MD, Teresa Mota- Huertas, APT, Sonia González-Castillo, MD, Rubén A. Cuesta, MD, José M. Tenias, MD, PhD, Teresa Bellón, PhD  Journal of Allergy and Clinical Immunology  Volume 128, Issue 5, Pages (November 2011) DOI: /j.jaci Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Masson trichrome staining of an endoscopic biopsy sample from an adult with EoE. The biopsy specimen was obtained with a single-side, open-type endoscopic biopsy forceps (Olympus FB-11K-1). We were able to sample deep esophageal tissue, including the epithelial stratum (a), LP (b), and up to the muscularis mucosae (c), where longitudinal smooth muscle fibers can be observed (original magnification ×100). Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 A–C, Density of intraepithelial and LP eosinophils in patients with EoE before and after treatment with fluticasone propionate compared with that seen in patients with GERD and healthy subjects expressed as an average ± SD. Because the data followed a normal distribution, they were checked with the Shapiro-Wilk test. ∗Statistically significant differences (P < .05) before and after treatment in patients with EoE. #Statistically significant differences (P < .05) between patients with EoE before treatment and patients with GERD. †Statistically significant differences (P < .05) between patients with EoE before treatment and normal esophagi. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Mean fibrosis scores in healthy subjects, patients with GERD, and patients with EoE before and after 1 year of topical treatment with fluticasone propionate. A, Median and interquartile ranges are represented in the boxes, with whiskers (vertical lines) extending to a limit of ± 1.5 interquartile range. B, Individual changes in fibrosis scores induced by prolonged fluticasone propionate treatment in patients with EoE. Bars represent means. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Masson trichrome staining of esophageal biopsies obtained from a subject with a normal esophagus (A), a patient with GERD (B), and a patient with EoE before (C) and after (D) 1 year of topical treatment with fluticasone propionate. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 5 Expression of profibrogenic cytokines in patients with EoE, patients with GERD, and control subjects (Normal) and changes induced in patients with EoE by prolonged treatment with fluticasone propionate (EoE before [EoE Before] and EoE after [EoE After] fluticasone propionate). Median and interquartile ranges are represented in the boxes, with whiskers (vertical lines) extending to a limit of ± 1.5 interquartile range. Individual changes in cytokine gene expression are provided. Horizontal bars represent means. A, IL-5; B, TGF-β1; C, FGF-9; D, CCL18. ∗Individual extreme values. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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