1. Phosphorylated CREB levels were assessed in the hippocampus at 20 min after cue and contextual fear conditioning.
Phosphorylated CREB levels were assessed in the hippocampus at 20 min after cue and contextual fear conditioning. A, Representative Western blots. B, Densitometric analysis. CREB phosphorylation significantly increased in sham animals after training, but not in TBI animals treated with vehicle 30 min before training (n = 6/group). Rolipram rescued the TBI-induced deficits in CREB phosphorylation after learning. *p < 0.05 versus untrained sham + vehicle animals, **p < 0.01 versus untrained sham + vehicle animals, (one-way ANOVA with Bonferroni's post hoc comparison). #p < 0.01 for TBI + vehicle versus TBI + rolipram animals (one-way ANOVA with Bonferroni's post hoc comparison).
David J. Titus et al. J. Neurosci. 2013;33:
©2013 by Society for Neuroscience