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Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma

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Presentation on theme: "Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma"— Presentation transcript:

1 Blocking IL-25 prevents airway hyperresponsiveness in allergic asthma
Sarah J. Ballantyne, BSc(Hons), Jillian L. Barlow, BSc(Hons), Helen E. Jolin, MA, Puneeta Nath, PhD, Alison S. Williams, BSc(Hons), Kian Fan Chung, MD DSc, Graham Sturton, PhD, See Heng Wong, PhD, Andrew N.J. McKenzie, PhD  Journal of Allergy and Clinical Immunology  Volume 120, Issue 6, Pages (December 2007) DOI: /j.jaci Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Neutralization of IL-25 prevents AHR. Pulmonary resistance in response to methacholine in OVA-sensitized mice. Data are combined from 2 experiments and represent the means ± SEMs of 14 to 18 mice/group. (∗P < .05 vs isotype control; ∗∗P < .01 vs isotype control). sens, Antibody administered before sensitization; aero, antibody administered before aerosol challenges. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Type 2 responses after neutralization of IL-25. A, Perivascular infiltration in lung sections. B, Mucus content. C, Antigen-specific serum IgE. D, Eosinophils in BAL. E, Antigen-induced cytokines. Symbols represent individuals; bar = mean. Data are representative of at least 2 independent experiments. aero, Antibody administered before aerosol challenges; sens, antibody administered before sensitization. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Lung histology after anti–IL-25 mAb treatment. A, Lung sections from anti–IL-25—treated and control animals stained with Giemsa to demonstrate infiltration of inflammatory cells. Representative sections are shown for each group. B, Lung sections from anti–IL-25—treated and control animals stained with periodic acid-Schiff to visualize mucin and mucous secreting cells. Representative sections are shown for each group. sens, Antibody administered before sensitization; aero, antibody administered before aerosol challenges. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 IL-25 regulates BAL IL-13 and IL-17, but does not directly induce smooth muscle contraction. A, Cytokine levels in BAL. B, Responses of rmIL-13 and rmIL-25–treated rat lung slices to 5-HT; representative slices shown. C, Response of rat lung slices to rmIL-25; representative slices shown. n = Data are representative of at least 2 independent experiments. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Fig 5 Administration of rmIL-25 to naive mice. Wild-type (A), il13–/–(B), or il4–/–il5–/–il9–/–il13–/–(C) mice were administered 1.8 μg rIL-25 or PBS intranasally. Methacholine sensitivity was determined 16 hours after challenge. n = 4-8 per group. Data are representative of at least 2 independent experiments. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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