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Are dust mite allergens more abundant and/or more stable than other Dermatophagoides pteronyssinus proteins?  Ryenne N. Ogburn, BS, Thomas A. Randall,

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Presentation on theme: "Are dust mite allergens more abundant and/or more stable than other Dermatophagoides pteronyssinus proteins?  Ryenne N. Ogburn, BS, Thomas A. Randall,"— Presentation transcript:

1 Are dust mite allergens more abundant and/or more stable than other Dermatophagoides pteronyssinus proteins?  Ryenne N. Ogburn, BS, Thomas A. Randall, PhD, Yingrong Xu, BS, Julia H. Roberts, BS, Betelihem Mebrahtu, Jaret M. Karnuta, S. Dean Rider, PhD, Grace E. Kissling, PhD, Robert E. London, PhD, Anna Pomés, PhD, Larry Arlian, PhD, Michael C. Fitzgerald, PhD, Geoffrey A. Mueller, PhD  Journal of Allergy and Clinical Immunology  Volume 139, Issue 3, Pages e1 (March 2017) DOI: /j.jaci Copyright © Terms and Conditions

2 Fig 1 Analysis of DP proteome and protein stability measurements. Histograms and box plots of relative expression (FPKM) of all DP transcripts (A), DP proteins studied for stability (B), and DP allergens (C). Panels D and E show histograms of the stability data for nonallergens and allergens, respectively, overlayed with Gaussian fits to the distribution. Panel F compares the Gaussian fit of stability data for the nonallergens (blue) with the allergens (red). Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © Terms and Conditions

3 Fig 2 Two-dimensional histograms of stability and relative expression for DP. Data are presented as a bar chart (A) or as a contour plot (B). Numerical labels indicate allergen groups. Three black circle sizes (large, medium, and small) correspond to the allergen importance rankings of major, mid-tier, and minor/“needs further study,” respectively.5 Dashed and dotted lines are the means for the nonallergen and allergen groups, respectively. Journal of Allergy and Clinical Immunology  , e1DOI: ( /j.jaci ) Copyright © Terms and Conditions

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