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Fig. 4 Structural details of tRNA binding to Elp123.
Structural details of tRNA binding to Elp123. (A) Structural superimposition of tRNA-bound (violet) and unbound Elp3 (gray). The contact points of neighboring Elp1 and Elp2 subunits are shown. r.m.s.d., Root-mean-square deviation. (B) Superimposition and close-up of the active site in the unbound (gray) and tRNA-bound (colored) Elp123 structure, highlighting potentially shifted residues (in bold). (C) Structural comparison between the Elp123-bound tRNAAlaUGC (middle) and different structural models from different templates (tRNAPheGAA PDB ID: 1EHZ, left; tRNAGluUUC PDB ID: 5HR6, right). Below, the differences between the ASL region of tRNAPheGAA (left) and tRNAAlaUGC bound to Elp123 are highlighted. For the Elp123-tRNA structure, the density in the ASL region is shown and the individual bases are labeled. (D) Close-up view of the ASL region bound to the central cavity of Elp3. Conserved basic residues and RNA bases in the anticodon loop are labeled. Maria I. Dauden et al. Sci Adv 2019;5:eaaw2326 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
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