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Fig. 2 The glucose binding and charge-switch study.
The glucose binding and charge-switch study. (A to C) Glucose concentration–dependent glucose-binding ability of F-insulin (A), B-insulin (B), and N-insulin (C). The complexes were incubated in glucose solutions (100, 200, or 400 mg/dl). Data points are means ± SD (n = 3). (D and E) Hydrodynamic size distribution determined by DLS and representative TEM images of nanoparticles prepared from poly(EDAA0.4-FPBA0.6) (D) and poly(EDAA0.4-PBA0.6) (E). (F) Glucose concentration–dependent ζ potentials of nanoparticles prepared from poly(EDAA0.4-FPBA0.6) and poly(EDAA0.4-PBA0.6). Data points are means ± SD (n = 3). Statistical significance was calculated using Student’s t test. ***P < NS, not significant. Jinqiang Wang et al. Sci Adv 2019;5:eaaw4357 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
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