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Fig. 3 Glucose- and structure-dependent insulin release.
Glucose- and structure-dependent insulin release. (A and B) Glucose-dependent insulin release from F-insulin (A) and B-insulin (B) over time. Insulin was labeled with rhodamine B. The glucose concentrations were set to 0, 100, 200, and 400 mg/dl. Data points are means ± SD (n = 3). a.u., arbitrary units. (C) Cumulative insulin release profile of F-insulin. The complex was incubated in each solution for 10 min. Data points are means ± SD (n = 3). (D) Pulsatile insulin release from F-insulin by alternating the glucose concentration. The complex was incubated in each solution for 2 min. Data points are means ± SD (n = 3). Jinqiang Wang et al. Sci Adv 2019;5:eaaw4357 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
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