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Slc7a5 in osteoblasts is dispensable for bone formation and bone homeostasis in vivo. Slc7a5 in osteoblasts is dispensable for bone formation and bone.

Published byFriedrich Klein Modified over 5 years ago

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Presentation on theme: "Slc7a5 in osteoblasts is dispensable for bone formation and bone homeostasis in vivo. Slc7a5 in osteoblasts is dispensable for bone formation and bone."— Presentation transcript:

1 Slc7a5 in osteoblasts is dispensable for bone formation and bone homeostasis in vivo.
Slc7a5 in osteoblasts is dispensable for bone formation and bone homeostasis in vivo. (A) Schematic diagram of the generation of osteoblast-specific Slc7a5 knockout mice. (B) Slc7a5 expression in the GFP-positive cells of control and Osx-Cre;Slc7a5fl/fl mice as determined by PCR. n = 3 mice per genotype. (C) μCT analysis, (D) BV/TV ratio as determined by μCT, (E) von Kossa staining, (F) BV/TV as determined by von Kossa staining, (G) TRAP staining, (H) Oc.S/BS ratio, (I) calcein labeling, (J) BFR, and (K) N.Ob/T.Ar of femurs from control and Osx-Cre;Slc7a5fl/fl mice at 12 weeks of age. n = 6 Osx-Cre mice; n = 8 Osx-Cre;Slc7a5fl/fl mice. All data were analyzed by the two-tailed Student’s t test. The double-headed white arrow in (I) indicates the distance between calcein double labeling. Scale bars, 1 mm (C and E), 100 μm (G), and 10 μm (I). Kakeru Ozaki et al., Sci. Signal. 2019;12:eaaw3921 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works

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