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Usa Tantibhaedhyangkul, MD, Carla M. Davis, MD, Lenora M

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Presentation on theme: "Usa Tantibhaedhyangkul, MD, Carla M. Davis, MD, Lenora M"— Presentation transcript:

1 Role of IL-7 in the regulation of T-cell homeostasis in partial DiGeorge syndrome 
Usa Tantibhaedhyangkul, MD, Carla M. Davis, MD, Lenora M. Noroski, MD, Imelda C. Hanson, MD, William T. Shearer, MD, PhD, Javier Chinen, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 123, Issue 4, Pages e2 (April 2009) DOI: /j.jaci Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 A-D, Correlation of TREC values and CD3+, CD4+, and CD4+CD45RA+ T-cell counts in all patients with pDGS. E-H, Patients with pDGS with “low T cells.” I-L, Patients with pDGS with “normal T-cells.” Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 The “low T cells” patient group had significantly lower TREC values and higher IL-7 levels than the “normal T cells” patient group. A and C, Median TRECs/1000 mononuclear cells and plasma IL-7 levels (in picograms per milliliter) were 26.0 and 7.3 in the “low T cells” group and and 3.3 in the “normal T cells” group, respectively. B, IL-7 levels were inversely correlated with TRECs in children with pDGS. Stars represent the 2 patients with low TREC values and low IL-7 levels. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions


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