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The rise and fall of horror autotoxicus and forbidden clones

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1 The rise and fall of horror autotoxicus and forbidden clones
J. Charles Jennette, Ronald J. Falk  Kidney International  Volume 78, Issue 6, Pages (September 2010) DOI: /ki Copyright © 2010 International Society of Nephrology Terms and Conditions

2 Figure 1 Normal immune homeostasis involves a balance between T cells, B cells, and antibodies that are reactive with self, non-self, or both. Disease results when there is an imbalance of immune responsivity with either too little immune defense against foreign pathogens (immune deficiency disease), more immune response to non-self antigens than is beneficial (allergic or hypersensitivity disease), or more immune response to self antigens than is beneficial (autoimmune disease). Kidney International  , DOI: ( /ki ) Copyright © 2010 International Society of Nephrology Terms and Conditions


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