1. Survival of the Fittest: Darwinian Selection Underpins Chemotherapy Resistance in AML 
Laura MacPherson, Mark A. Dawson 
Cell Stem Cell 
Volume 21, Issue 3, Pages (September 2017)
DOI: /j.stem
Copyright © 2017 Elsevier Inc. Terms and Conditions

2. Figure 1 Schematic of the Two Major Patterns of Relapse in AML
(A) Relapse origin-primitive (ROP). Relapse was traced to rare immature HSPC-like leukemia cells that were chemoresistant. This pattern demonstrates a deep hierarchal organization whereby only a rare population of HSPC-like leukemia cells express a stem cell program.
(B) Relapse origin-committed (ROC). Relapse was traced to a more mature CD33+ blast population with a strong LSC-like transcriptional program. This pattern of relapse demonstrates a shallow hierarchal organization. The CD33+ blast population that persists post-therapy could be potentially targeted with anti-CD33 maintenance.
Cell Stem Cell  , DOI: ( /j.stem )
Copyright © 2017 Elsevier Inc. Terms and Conditions