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The Impact of In Vivo Reflectance Confocal Microscopy for the Diagnostic Accuracy of Melanoma and Equivocal Melanocytic Lesions  Giovanni Pellacani, Pascale.

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Presentation on theme: "The Impact of In Vivo Reflectance Confocal Microscopy for the Diagnostic Accuracy of Melanoma and Equivocal Melanocytic Lesions  Giovanni Pellacani, Pascale."— Presentation transcript:

1 The Impact of In Vivo Reflectance Confocal Microscopy for the Diagnostic Accuracy of Melanoma and Equivocal Melanocytic Lesions  Giovanni Pellacani, Pascale Guitera, Caterina Longo, Michelle Avramidis, Stefania Seidenari, Scott Menzies  Journal of Investigative Dermatology  Volume 127, Issue 12, Pages (December 2007) DOI: /sj.jid Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

2 Figure 1 In vivo confocal microscopic features characteristic for melanomas. (a) Suprabasal epidermis disarray, with unevenly distributed bright granular particles and pagetoid cells; (b) atypical cells in sheet-like structures at the dermal–epidermal junction; (c) non-homogeneous nests, constituted by aggregates of mixed dense and sparse cell. Bar=50μm. Journal of Investigative Dermatology  , DOI: ( /sj.jid ) Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

3 Figure 2 In vivo confocal microscopic features characteristic for nevi. (a) Regular honeycombed and cobblestone pattern; (b) regular junctional nests of cells (junctional cluster and junctional thickening); (c) regular dense nests in the dermis. Bar=50μm. Journal of Investigative Dermatology  , DOI: ( /sj.jid ) Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions

4 Figure 3 Model selection and estimation used only the training set, whereas ROC analysis used only the test set. (a) ROC curve obtained by means of discriminant analysis (AUC=0.833); (b) ROC curve from binary logistic regression (AUC=0.827); (c) ROC curve from RCM score algorithm (AUC=0.852). Journal of Investigative Dermatology  , DOI: ( /sj.jid ) Copyright © 2007 The Society for Investigative Dermatology, Inc Terms and Conditions


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