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Pharmacological analysis of four mutant receptors compared with wild-type GLP-1R: Lys-288–Ala4.64, Asn-300–AlaECL2, Trp-306–Ala5.36 or Arg-310–Ala5.40.

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Presentation on theme: "Pharmacological analysis of four mutant receptors compared with wild-type GLP-1R: Lys-288–Ala4.64, Asn-300–AlaECL2, Trp-306–Ala5.36 or Arg-310–Ala5.40."— Presentation transcript:

1 Pharmacological analysis of four mutant receptors compared with wild-type GLP-1R: Lys-288–Ala4.64, Asn-300–AlaECL2, Trp-306–Ala5.36 or Arg-310–Ala5.40 Pharmacological analysis of four mutant receptors compared with wild-type GLP-1R: Lys-288–Ala4.64, Asn-300–AlaECL2, Trp-306–Ala5.36 or Arg-310–Ala5.40 (A) Concentration–response curves for GLP-1-induced cAMP accumulation in Flp-In HEK293 cells. US, unstimulated (no GLP-1 added). (B) Radioligand competition binding curves, using 75 pM 125I-EX4(9–39) and unlabelled GLP-1 as competitor, for membranes derived from Flp-In HEK293 cells expressing either wild-type GLP-1R or one of four single site mutant receptors. Replicates are in triplicate with errors representing S.E.M. Rachel L. Dods, and Dan Donnelly Biosci. Rep. 2016;36:e00285 ©2016 by Portland Press Ltd

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