1. The MEG3 promoter and enhancer interact with other putative enhancers within the DLK1-MEG3–imprinted region.
The MEG3 promoter and enhancer interact with other putative enhancers within the DLK1-MEG3–imprinted region. Genome browser image of the selective interactions of the MEG3 promoter and enhancer within 350 kb of the MEG3 promoter. 4C-Seq was performed using the MEG3 promoter and enhancer, respectively, as viewpoints (indicated with red triangles) using three human islet donors (represented by different shaded tracks) per viewpoint. Bars under each track represent the significant interaction sites (P < 1 × 10−8). The MEG3 promoter and enhancer make frequent contact with putative enhancers within the imprinted locus. ChIP sequencing for the histone modification marks and the putative enhancer identification was performed by Pasquali et al. (15).
Vasumathi Kameswaran et al. Diabetes 2018;67:
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