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The Side Story of Stem-like Glioma Cells

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1 The Side Story of Stem-like Glioma Cells
Anders I. Persson, William A. Weiss  Cell Stem Cell  Volume 4, Issue 3, Pages (March 2009) DOI: /j.stem Copyright © 2009 Elsevier Inc. Terms and Conditions

2 Figure 1 Models to Describe How Loss of PTEN and Treatment with Temozolomide May Lead to Chemoresistance in Glioma (A) Loss of PTEN leads to increased ABCG2 activity (represented by black squares) in a subset of cells, resulting in increased self-renewal and net chemoresistance. (B) The alkylating agent temozolomide most effectively targets non-SP cells, leading to relative expansion of a chemoresistant (ABCG2-positive) SP fraction. Cell Stem Cell 2009 4, DOI: ( /j.stem ) Copyright © 2009 Elsevier Inc. Terms and Conditions


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