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MR1Ts are recognized by hpMR1 tetramers loaded with a heterogeneous mixture of microbially derived ligands. MR1Ts are recognized by hpMR1 tetramers loaded.

Published byΑρισταίος Βλαστός Modified over 5 years ago

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Presentation on theme: "MR1Ts are recognized by hpMR1 tetramers loaded with a heterogeneous mixture of microbially derived ligands. MR1Ts are recognized by hpMR1 tetramers loaded."— Presentation transcript:

1 MR1Ts are recognized by hpMR1 tetramers loaded with a heterogeneous mixture of microbially derived ligands. MR1Ts are recognized by hpMR1 tetramers loaded with a heterogeneous mixture of microbially derived ligands. (A to C) PBMCs from 15 donors were stained with the hpMR1+EC tetramer (12.5 nM per test) or the MR1/5-OP-RU tetramer (1:500; NIH tetramer core) and a panel of phenotypic markers. (A) Representative dot plots for three donors. Blue boxes denote the frequency of CD3+CD4− tetramer+ cells. All plots are log scales. (B) The graphs depict the frequency of CD3+CD4−MR1/5-OP-RU or hpMR1+EC tetramer+ cells for all 15 PBMC donors. (C) The graphs in (B) are paired to demonstrate the relationship between the hpMR1+EC and MR1/5-OP-RU for each donor. Melanie J. Harriff et al. Sci. Immunol. 2018;3:eaao2556 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

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