1. Low/moderate intensity statins High intensity statins
In PAD, statin therapy was associated with a significant reduction of amputations and mortality compared with no statin use
Outcome
Low/moderate intensity statins
High intensity statins
Mortality
HRadj: 0.83; 95%CI:
HRadj: 0.74; 95%CI:
Amputations
HRadj: 0.81; 95%CI:
HRadj: 0.67; 95%CI:
PAD: peripheral artery disease; Adjusted for age, PAD diagnosis year, race, gender, socio-economic status, body mass index, comorbidities, including diabetes, hypertension, heart failure, chronic obstructive pulmonary disease, atrial fibrillation, carotid disease, depression, chronic kidney disease and end stage renal disease, antiplatelet medications, cilostazol, PAD severity, and serum creatinine
Arya et al. Circulation 2018