1. Oxidative stress, superoxide, and Pdx-1 levels in pancreatic islets of diabetic mice.
Oxidative stress, superoxide, and Pdx-1 levels in pancreatic islets of diabetic mice. A: Representative images of 4-HNE staining (brown, indicated by arrows) in cross sections of mouse pancreatic islets. B: The percentage of 4-HNE–positive cells in pancreatic islets. C: Representative images of DHE staining (red) in pancreatic islets. D: Quantification of superoxide levels (DHE staining) in pancreatic islets. E: Representative images of Pdx-1 staining in pancreatic islets. F: Semiquantification of Pdx-1 staining in pancreatic islets. Data are mean ± SEM. n = 4–5 animals/group. ***P < vs. the lean-PBS group; +P < 0.05, +++P < vs. the db/db-PBS group. ab, antibody; w/o, without.
Yi Lin, and Zhongjie Sun Diabetes 2015;64:
©2015 by American Diabetes Association