Presentation is loading. Please wait.

Presentation is loading. Please wait.

Age-related differences in the pathogenesis of chronic rhinosinusitis

Published bySri Tanuwidjaja Modified over 5 years ago

Similar presentations

Presentation on theme: "Age-related differences in the pathogenesis of chronic rhinosinusitis"— Presentation transcript:

1 Age-related differences in the pathogenesis of chronic rhinosinusitis
Seong H. Cho, MD, Seung J. Hong, MD, PhD, Brian Han, BA, Sun H. Lee, PhD, Lydia Suh, BSc, James Norton, MSc, David Lin, BA, David B. Conley, MD, Rakesh Chandra, MD, Robert C. Kern, MD, Bruce K. Tan, MD, Atsushi Kato, PhD, Anju Peters, MD, Leslie C. Grammer, MD, Robert P. Schleimer, PhD  Journal of Allergy and Clinical Immunology  Volume 129, Issue 3, Pages e2 (March 2012) DOI: /j.jaci Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Age-related distribution of the ECP and HNE protein levels in nasal lavage fluids from normal subjects and from patients with CRS as determined by ELISA. A, In the CRSwNP subtype, ECP levels in elderly patients were significantly lower compared with those in nonelderly patients. B and C, There was a significant negative correlation between ECP levels and age in patients with CRSwNP, but not in patients with CRSsNP. D-F, The HNE levels from normal subjects and from patients with CRS were not different by age, and there was no correlation between HNE levels with aging. E, Elderly; NE, nonelderly. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Age-related distribution of the human S100A8/A9 protein levels in nasal lavage fluids from normal subjects and from patients with CRS as determined by ELISA. A, In normal controls and patients with CRSsNP, S100A8/9 levels in elderly subjects were significantly lower compared with those in nonelderly subjects. B-D, Levels of S100A8/A9 were significantly diminished with increasing age in normal controls and patients with both subtypes of CRS. E, Elderly; NE, nonelderly. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E1 Age-related distribution of the ECP and HNE protein levels in nasal lavage fluids from normal subjects as determined by ELISA. There was no significant correlation between age and levels of ECP (A) or HNE (B). Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Download ppt "Age-related differences in the pathogenesis of chronic rhinosinusitis"

Similar presentations

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,

Joint modeling of parentally reported and physician-confirmed wheeze identifies children with persistent troublesome wheezing Danielle C.M. Belgrave, MSc,
A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay Jing Lin, PhD, Francesca M. Bruni,
Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,

Early exposure to cow's milk protein is protective against IgE-mediated cow's milk protein allergy Yitzhak Katz, MD, Nelly Rajuan, MSc, Michael R. Goldberg,
Transient receptor potential vanilloid 1 (TRPV1) antagonism in patients with refractory chronic cough: A double-blind randomized controlled trial Saifudin.

Transient receptor potential vanilloid 1 (TRPV1) antagonism in patients with refractory chronic cough: A double-blind randomized controlled trial Saifudin.
Characteristics of childhood peanut allergy in the Australian Capital Territory, 1995 to 2007 Raymond James Mullins, MBBS, PhD, FRACP, FRCPA, Keith B.G.

Characteristics of childhood peanut allergy in the Australian Capital Territory, 1995 to 2007 Raymond James Mullins, MBBS, PhD, FRACP, FRCPA, Keith B.G.
Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation So Ri Kim, MD, PhD, Dong Im Kim, MS, Mi.

Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor κB activation So Ri Kim, MD, PhD, Dong Im Kim, MS, Mi.
Lower vitamin D status is closely correlated with eczema of the head and neck  Seongmin Noh, MD, Chang Ook Park, MD, Jung Min Bae, MD, Jungsoo Lee, MD,

Lower vitamin D status is closely correlated with eczema of the head and neck  Seongmin Noh, MD, Chang Ook Park, MD, Jung Min Bae, MD, Jungsoo Lee, MD,
D-dimer: A biomarker for antihistamine-resistant chronic urticaria

D-dimer: A biomarker for antihistamine-resistant chronic urticaria
Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 

Jonathan A. Bernstein, MD, David M. Lang, MD, David A. Khan, MD 
Proton pump inhibitors decrease eotaxin-3/CCL26 expression in patients with chronic rhinosinusitis with nasal polyps: Possible role of the nongastric.

Proton pump inhibitors decrease eotaxin-3/CCL26 expression in patients with chronic rhinosinusitis with nasal polyps: Possible role of the nongastric.
Anju T. Peters, MD, Atsushi Kato, PhD, Ning Zhang, PhD, David B

Anju T. Peters, MD, Atsushi Kato, PhD, Ning Zhang, PhD, David B
Genetic variation in B cell–activating factor of the TNF family (BAFF) and asthma exacerbations among African American subjects  Rajesh Kumar, MD, MS,

Genetic variation in B cell–activating factor of the TNF family (BAFF) and asthma exacerbations among African American subjects  Rajesh Kumar, MD, MS,
Lower vitamin D status is closely correlated with eczema of the head and neck  Seongmin Noh, MD, Chang Ook Park, MD, Jung Min Bae, MD, Jungsoo Lee, MD,

Lower vitamin D status is closely correlated with eczema of the head and neck  Seongmin Noh, MD, Chang Ook Park, MD, Jung Min Bae, MD, Jungsoo Lee, MD,
Endotype-driven care pathways in patients with chronic rhinosinusitis

Endotype-driven care pathways in patients with chronic rhinosinusitis
Proton pump inhibitors decrease eotaxin-3/CCL26 expression in patients with chronic rhinosinusitis with nasal polyps: Possible role of the nongastric.

Proton pump inhibitors decrease eotaxin-3/CCL26 expression in patients with chronic rhinosinusitis with nasal polyps: Possible role of the nongastric.
Heterogeneous inflammatory patterns in chronic rhinosinusitis without nasal polyps in Chicago, Illinois  Bruce K. Tan, MD, MS, Aiko I. Klingler, PhD,

Heterogeneous inflammatory patterns in chronic rhinosinusitis without nasal polyps in Chicago, Illinois  Bruce K. Tan, MD, MS, Aiko I. Klingler, PhD,
Evidence for intranasal antinuclear autoantibodies in patients with chronic rhinosinusitis with nasal polyps  Bruce K. Tan, MD, Quan-Zhen Li, PhD, Lydia.

Evidence for intranasal antinuclear autoantibodies in patients with chronic rhinosinusitis with nasal polyps  Bruce K. Tan, MD, Quan-Zhen Li, PhD, Lydia.
Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD 
Robert M. Naclerio, MD, Jayant Pinto, MD, Fuad Baroody, MD 

Robert M. Naclerio, MD, Jayant Pinto, MD, Fuad Baroody, MD 
Anju T. Peters, MD, Atsushi Kato, PhD, Ning Zhang, PhD, David B

Anju T. Peters, MD, Atsushi Kato, PhD, Ning Zhang, PhD, David B

Similar presentations

Ads by Google