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Lipid transfer protein–linked hazelnut allergy in children from a non-Mediterranean birch- endemic area  Annebeth E. Flinterman, MD, Jaap H. Akkerdaas,

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Presentation on theme: "Lipid transfer protein–linked hazelnut allergy in children from a non-Mediterranean birch- endemic area  Annebeth E. Flinterman, MD, Jaap H. Akkerdaas,"— Presentation transcript:

1 Lipid transfer protein–linked hazelnut allergy in children from a non-Mediterranean birch- endemic area  Annebeth E. Flinterman, MD, Jaap H. Akkerdaas, PhD, Constance F. den Hartog Jager, BSc, Neil M. Rigby, BSc, Montserrat Fernandez- Rivas, MD, PhD, Maarten O. Hoekstra, MD, PhD, Carla A. Bruijnzeel-Koomen, MD, PhD, André C. Knulst, MD, PhD, Ronald van Ree, PhD, Suzanne G. Pasmans, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 121, Issue 2, Pages e2 (February 2008) DOI: /j.jaci Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 ROC curves for nCor a 8, nCor a 2, and nCor a 1 determined for the group that underwent DBPCFCs with hazelnut. The group with no reaction and OAS was regarded as negative, and the group with objective reactions was regarded as positive. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Immunoblots with hazelnut extract for all children who underwent DBPCFCs with hazelnut. The numbers under each lane correspond with the numbers of the children in Table I. The first lanes on the second row (C1 and C2) represent a nonatopic control and secondary antibody alone. The bottom row consists of immunoblots with nCor a 8 for all children with objective reactions to hazelnut. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Inhibition of hazelnut immunoblots with nCor a 8 for 2 subjects with objective symptoms (25 and 27). The bands around 8 kd are inhibited by nCor a 8. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig 4 Prevalence of sensitization to nBet v 1, nCor a 1, and nCor a 8 in different age groups (range, 0.5–16.6 years; median, 4.5). The horizontal axis represents the different age groups. Age group 0 consists of children aged 0.01 to 1.00 years and so on. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

6 Silver staining of purified Cor a 1 and Cor a 8.
Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

7 Silver staining of purified Cor a 8 at several concentrations
Silver staining of purified Cor a 8 at several concentrations. Mw, Molecular weight. Journal of Allergy and Clinical Immunology  , e2DOI: ( /j.jaci ) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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