1. Liver fibrosis after CCl4 injury in 5αR1-KO and WT mice.
Liver fibrosis after CCl4 injury in 5αR1-KO and WT mice. Representative images of liver sections (5 µm) stained with picrosirius red to show collagen deposition. Collagen is not detected in WT mice (A) or KO mice (B) receiving injections of vehicle. Mice deficient in 5αR1 have greater induction of collagen after CCl4 administration, including evidence of bridging fibrosis (KO) (D), compared with WT controls (C).
Dawn E.W. Livingstone et al. Diabetes 2015;64:
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