1. Effect of age on the clinical profile and systemic absorption and disposition of levobupivacaine after epidural administration 
Simon M.J.G. , Veering B.T. , Stienstra R. , van Kleef J.W. , Burm A.G.L.  
British Journal of Anaesthesia 
Volume 93, Issue 4, Pages (October 2004)
DOI: /bja/aeh241
Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

2. Fig 1
Mean and individual values for the upper level of anaesthesia during epidural anaesthesia with levobupivacaine 0.75% for the three age groups (Group 1, 18–44 yr; Group 2, 45–70 yr; Group 3, >70 yr). Data are averages of the levels measured on the right and left side of the trunk.
British Journal of Anaesthesia  , DOI: ( /bja/aeh241)
Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

3. Fig 2
Plasma concentrations after (a) i.v. infusion of D3-levobupivacaine and (b) epidural administration of levobupivacaine in individual subjects.
British Journal of Anaesthesia  , DOI: ( /bja/aeh241)
Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

4. Fig 3
Cumulative fractions absorbed of levobupivacaine vs time in individual surgical patients. Absorption–time data were obtained by deconvolution of the measured concentrations unlabelled levobupivacaine concentration–time data against the i.v. unit impulse–response curve, derived from the D3-levobupivacaine concentration–time data.
British Journal of Anaesthesia  , DOI: ( /bja/aeh241)
Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

5. Fig 4
Graphical representation of the relationship between the peak plasma concentrations (Cmax) and the fractions absorbed during the initial absorption phase (F1) for the youngest, middle, and oldest age group of patients. In the entire study population, a larger F1 was associated with a higher Cmax.
British Journal of Anaesthesia  , DOI: ( /bja/aeh241)
Copyright © 2004 British Journal of Anaesthesia Terms and Conditions