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Acute onset/flares of dermatomyositis following ingestion of IsaLean herbal supplement: Clinical and immunostimulatory findings  Majid Zeidi, MD, Peter.

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Presentation on theme: "Acute onset/flares of dermatomyositis following ingestion of IsaLean herbal supplement: Clinical and immunostimulatory findings  Majid Zeidi, MD, Peter."— Presentation transcript:

1 Acute onset/flares of dermatomyositis following ingestion of IsaLean herbal supplement: Clinical and immunostimulatory findings  Majid Zeidi, MD, Peter B. Chansky, MD, Victoria P. Werth, MD  Journal of the American Academy of Dermatology  Volume 80, Issue 3, Pages (March 2019) DOI: /j.jaad Copyright © Terms and Conditions

2 Fig 1 Photograph of patient 1 showing facial erythema, heliotrope rash, and V sign. Skin biopsy specimen of patient 1 (hematoxylin-eosin stain; original magnification: ×20) showing subtle vacuolar changes within the basal keratinocytes, dilated blood vessels, and sparse superficial lymphocytic infiltrates. Photograph of patient 2 showing the Gottron sign on the dorsal aspect of the hands. Skin biopsy specimen of patient 2 (hematoxylin-eosin stain; original magnification: ×20) with dermatomyositis showing interface dermatitis with vacuolization of basal keratinocytes, dilated blood vessels, and sparse superficial lymphocytic infiltrates (poikilodermatous changes); a thickened basement membrane is seen in the insert (periodic acid–Schiff stain; original magnification: ×40). Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © Terms and Conditions

3 Fig 2 Secretion of tumor necrosis factor-α (TNF-α), interferon-α (IFN-α), and interferon beta (IFN-β) from unstimulated peripheral blood mononuclear cells (PBMCs) of patients with dermatomyositis and from PBMCs of the same patients that have been stimulated with different concentrations of IsaLean. Effects of anti–Toll-like receptor (TLR4) antibody versus sham on secretion of TNF-α from the unstimulated and lipopolysaccharide (LPS)- and IsaLean-stimulated PBMCs of patients with dermatomyositis. Effects of quinacrine (QC) and hydroxychloroquine (HCQ) versus sham on secretion of TNF-α from the unstimulated and IsaLean-stimulated PBMCs of patients with dermatomyositis (n = 5). ns, Not significant. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © Terms and Conditions

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