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Sam68 Guest STARs in TNF-α Signaling

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Presentation on theme: "Sam68 Guest STARs in TNF-α Signaling"— Presentation transcript:

1 Sam68 Guest STARs in TNF-α Signaling
Gregory T. Kunkel, Xiaodong Wang  Molecular Cell  Volume 43, Issue 2, Pages (July 2011) DOI: /j.molcel Copyright © 2011 Elsevier Inc. Terms and Conditions

2 Figure 1 Role of Sam68 in TNF-α Signaling
In the absence of ligand, Sam68 interacts with FADD. Upon activation with TNF-α, Sam68 is recruited to TNFR1, where it stabilizes cIAP1 and TRAF2, allowing RIPK1 ubiquitylation and NF-κB activation. TNFR1 is internalized; RIPK1 and Sam68 disassociate from the receptor and form a complex with FADD and caspase-8, leading to caspase activation and cell death. Molecular Cell  , DOI: ( /j.molcel ) Copyright © 2011 Elsevier Inc. Terms and Conditions

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