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IT1t suppresses TLR7-mediated inflammation in tonsil resident pDCs

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Presentation on theme: "IT1t suppresses TLR7-mediated inflammation in tonsil resident pDCs"— Presentation transcript:

1 Fig. 4 IT1t suppresses TLR7-mediated inflammation in tonsil resident pDCs.
IT1t suppresses TLR7-mediated inflammation in tonsil resident pDCs. (A) Picture of human tonsil after surgical removal. (B) pDCs from tonsils were identified as CD8-CD3-CD16-CD14-CD123 + HLADR+BDCA-4+. (C) Percentage of pDCs within the Lin−DR+ cells from eight human tonsils. (D) TMCs of healthy individuals were cultured with R848 (5 μg/ml) in the presence or absence of IT1t (20 μM). IFN+ pDCs were identified and quantified by flow cytometry. (E and F) Effect of IT1t on R848-stimualted TMCs was evaluated in the supernatant of seven healthy individuals using LEGENDplex. (E) Heat map represents the fold increase in cytokine secretion compared to NS. “*” represents the statistical analysis comparing the R848 to the NS condition. “X” represents the statistical analysis comparing the R848 to the R848 + IT1t condition. (F) Graphs represent the concentration in picograms per milliliter of each measured cytokine. Box and whisker plots with median ± minimum to maximum. Friedman test with Dunn’s post hoc correction. *** or XXXP < 0.001, ** or XXP < 0.01, * or XP < (Photo credit: N. Smith, CNRS UMR‑8601, CBMIT, Université Paris Descartes, Paris, France, and Institute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.) NS, nonstimulated. Nikaïa Smith et al. Sci Adv 2019;5:eaav9019 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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