1. CIE does not alter D2/D4 receptor expression in the mPFC.
CIE does not alter D2/D4 receptor expression in the mPFC. A, Coronal view of the rat brain atlas of the mPFC showing the region (gray box) of analysis of D2/D4 receptor expression. B, Quantitative autoradiography of D2 receptor binding using [3H]raclopride (left graph) and D4 receptor binding with [3H]nemonapride (right graph) demonstrating no difference in specific binding between control and CIE-exposed rats (1 week withdrawal; n = 8/group; p = 0.60, unpaired t test). C, CIE exposure was associated with an increase in D2 receptor-stimulated [35S]GTPγS binding (CIE: n = 7; control: n = 6; *p < 0.02, unpaired t test). D, CIE exposure did not alter the number of D2 receptor-IR-positive cells in the mPFC (n = 6/group; p = 0.27, unpaired t test). Scale bar, 100 μm.
Heather Trantham-Davidson et al. J. Neurosci. 2014;34:
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