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Increased platelet deposition on polytetrafluoroethylene grafts after balloon catheter thrombectomy
Fritz R. Bech, MD, Spencer W. Galt, MD, Jack L. Cronenwett, MD Journal of Vascular Surgery Volume 11, Issue 6, Pages (June 1990) DOI: / (90)90077-N Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions
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Fig. 1 Three different models of graft thrombosis were created weekly in each dog for 3 weeks, resulting in nine thrombosed grafts per dog. In situ grafts were anastomosed end to end to the femoral or carotid artery and oversewn distally. In vivo grafts were filled with blood, oversewn at both ends, and placed in the subcutaneous tissue near the in situ grafts. In vitro grafts were filled with blood, clamped, and placed in a saline water bath. Journal of Vascular Surgery , DOI: ( / (90)90077-N) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions
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Fig. 2 Platelet deposition on grafts briefly exposed to plasma and blood (n = 3 dogs) and on thrombectomized grafts of each thrombosis model type (n = 8 dogs) expressed as the ratio (± SEM) of the study grafts to the control (new) grafts. Platelet deposition was measured by 111In-labeled platelet counting normalized for circulating blood. Thrombectomized graft data represent the mean of 1-, 2-, and 3-week thrombus duration. All three thrombectomized graft models accumulated significantly more platelets than did new control grafts (p < 0.05). Journal of Vascular Surgery , DOI: ( / (90)90077-N) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions
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Fig. 3 Platelet deposition on thrombectomized grafts (n = 8 dogs) according to the duration of thrombosis (mean of three thrombosis models) expressed as the ratio (±SEM) of thrombectomized to control grafts. The tendency for increased platelet deposition from 1 to 3 weeks was not statistically significant. Journal of Vascular Surgery , DOI: ( / (90)90077-N) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions
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Fig. 4 Platelet deposition on 1 cm segments of control and thrombectomized grafts (n = 8 dogs; mean of 1-, 2-, and 3-week thrombus duration). Segments A to E represent proximal to distal segments in the flow circuit for all grafts. Segment A in in situ grafts represents the anastomotic end of the graft animal, whereas segment E represents the blind end. Platelet deposition is expressed as 111In cpm per cm graft/111In cpm per 100 μl of circulating blood. Journal of Vascular Surgery , DOI: ( / (90)90077-N) Copyright © 1990 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions
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