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Mechanism of higher incidence of ischemic mitral regurgitation in patients with inferior myocardial infarction: Quantitative analysis of left ventricular.

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Presentation on theme: "Mechanism of higher incidence of ischemic mitral regurgitation in patients with inferior myocardial infarction: Quantitative analysis of left ventricular."— Presentation transcript:

1 Mechanism of higher incidence of ischemic mitral regurgitation in patients with inferior myocardial infarction: Quantitative analysis of left ventricular and mitral valve geometry in 103 patients with prior myocardial infarction  Toshiro Kumanohoso, MDa, Yutaka Otsuji, MDa, Shiro Yoshifuku, MDa, Keiko Matsukida, MDa, Chihaya Koriyama, MDb, Akira Kisanuki, MDa, Shinichi Minagoe, MDa, Robert A. Levine, MDc, Chuwa Tei, MDa  The Journal of Thoracic and Cardiovascular Surgery  Volume 125, Issue 1, Pages (January 2003) DOI: /mtc Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

2 Dr Kumanohoso and colleagues
The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

3 Fig. 1 Leaflet-tethering hypothesis for the mechanism of mitral leaflet tenting and functional MR: left, normal leaflet tethering in a normal subject; right, augmented leaflet tethering resulting in apical displacement of the mitral leaflets and MR caused by LV dilation, systolic LV regional wall motion abnormalities, or both. MLT, Mitral leaflet tenting; LA, left atrium; Ao, aorta; AML, anterior mitral leaflet; PML, posterior mitral leaflet. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

4 Fig. 2 Methods to measure (1) the mitral annular area from 2 diameters in apical views, (2) the mitral leaflet-tenting area between the mitral leaflets and a line connecting mitral annular hinge points in the midsystolic apical 4-chamber view (dashed area shown in the left panel), and (3) leaflet-tethering lengths between anterior or posterior PM tips and contralateral anterior mitral annulus (ℓ1 and ℓ2). LV, Left ventricle; LA, left atrium; RV, right ventricle; RA, right atrium. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

5 Fig. 3 Bar graphs showing differences in mitral leaflet-tenting area, percentage of MR jet area, and anterior or posterior PM-tethering distances between patients with anterior and inferior infarction. NS, Not significant. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

6 Fig. 4 Scattergraphs showing relationships between mitral leaflet-tenting area and its determinants. Multiple stepwise regression analysis identified the increase in posterior PM-tethering distance/BSA as an independent contributing factor to the mitral leaflet-tenting area, along with mitral annular area/BSA and inferior MI location. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions

7 Fig. 5 Scattergraphs showing relationships between percentage of MR jet area and its determinants. Multiple stepwise regression analysis identified the increase in posterior PM-tethering distance/BSA as an independent contributing factor to the percentage of MR jet area, along with LV end-diastolic volume/BSA, inferior MI location, and mitral annular area. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /mtc ) Copyright © 2003 American Association for Thoracic Surgery Terms and Conditions


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